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Article

Building a potent TREM2 agonistic, biparatopic, common light chain antibody

13 Aug 2025

Abstract excerpt

Triggering Receptor Expressed on Myeloid cells 2 (TREM2) plays an important role in microglial function and has been genetically linked to Alzheimer's disease. Activation of TREM2 signaling may contribute to protection against neurotoxic effects of amyloid. Numerous TREM2 activating antibodies have been shown to modulate downstream microglial functions to different degrees, with mixed results in preclinical...

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PMID: 40803893
DOI: 10.1080/19420862.2025.2546554

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