Article

Molecular Dynamics simulations of TREM2 variants R47H and R62H show structural alterations at key binding regions leading to possible implications for mechanisms in Alzheimer’s disease.

2019-11-26

Abstract excerpt

<title>Abstract</title> <p>Background There is strong evidence supporting the association between Alzheimer’s disease (AD) and protein-coding variants, R47H and R62H in triggering receptor expressed on myeloid cells 2 (TREM2). The TREM2 protein is an immune receptor protein found in brain microglia. These two variants are in a similar position in the protein but cause a different functional outcome. A structural...

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Literature Corpus work: 802d4d75-fa55-5c40-befa-6bda715f83b9
DOI: 10.21203/rs.2.15314/v2

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