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Article

Molecular basis for the loss-of-function effects of the Alzheimer's disease-associated R47H variant of the immune receptor TREM2.

The Journal of biological chemistry - 10 Aug 2018

Sudom Athena, Talreja Santosh, Danao Jean, Bragg Eric, Kegel Rob, Min Xiaoshan, Richardson Jason, Zhang Zhongqi, Sharkov Nikolai, Marcora Edoardo, Thibault Steve, Bradley Jodi, Wood Steve, Lim Ai-Ching, Chen Hang, Wang Songli, Foltz Ian N, Sambashivan Shilpa, Wang Zhulun

Abstract excerpt

Triggering receptor expressed on myeloid cells 2 (TREM2) is an immune receptor expressed on the surface of microglia, macrophages, dendritic cells, and osteoclasts. The R47H TREM2 variant is a significant risk factor for late-onset Alzheimer's disease (AD), and the molecular basis of R47H TREM2 loss of function is an emerging area of TREM2 biology. Here, we report three high-resolution structures of the...

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Source

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Identifiers

PMID: 29794134
DOI: 10.1074/jbc.RA118.002352
PMCID: PMC6093241

Genes

TREM2
CDR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Molecular basis for the loss-of-function effects of the Alzheimer's disease-associated R47H variant of the immune receptor TREM2.PMID 29794134Read ↗

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