Article

Chemogenetic tuning reveals optimal MAPK signaling for cell-fate programming

2024-12-22

Abstract excerpt

Cell states evolve through the combined activity of signaling pathways and gene regulatory networks. While transcription factors can direct cell fate, these factors rely on a cell state that is receptive to transitions in cell identity. How signaling levels contribute to the emergence of receptive cell states remains poorly defined in primary cells. Using a well-defined model of direct conversion, we examined how...

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Literature Corpus work: c3a1396d-f174-5047-b003-89a3cf9a5fb0
DOI: 10.1101/2024.12.19.629350

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