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Article

Control of cell state transitions.

Nature - 1 Sept 2022

Rukhlenko Oleksii S, Halasz Melinda, Rauch Nora, Zhernovkov Vadim, Prince Thomas, Wynne Kieran, Maher Stephanie, Kashdan Eugene, MacLeod Kenneth, Carragher Neil O, Kolch Walter, Kholodenko Boris N

Abstract excerpt

Understanding cell state transitions and purposefully controlling them is a longstanding challenge in biology. Here we present cell state transition assessment and regulation (cSTAR), an approach for mapping cell states, modelling transitions between them and predicting targeted interventions to convert cell fate decisions. cSTAR uses omics data as input, classifies cell states, and develops a workflow that...

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Identifiers

PMID: 36104561
DOI: 10.1038/s41586-022-05194-y
PMCID: PMC9644236

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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