Article

Balancing dynamic tradeoffs drives cellular reprogramming

2018-08-17

Abstract excerpt

Although cellular reprogramming continues to generate new cell types, reprogramming remains a rare cellular event. The molecular mechanisms that limit reprogramming, particularly to somatic lineages, remain unclear. By examining fibroblast-to-motor neuron conversion, we identify a previously unappreciated dynamic between transcription and replication that determines reprogramming competency. Transcription factor o...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d389e45c-70cb-50d2-bfd9-a7f89dac5093
DOI: 10.1101/393934

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Balancing dynamic tradeoffs drives cellular reprogrammingDOI 10.1101/393934Read

Proliferation history and transcription factor levels drive direct conversionSemantic proximity Read

DNA replication fork speed underlies cell fate changes and promotes reprogrammingSemantic proximity Read

Cellular reprogramming – lowering gravity on Waddington's epigenetic landscapeSemantic proximity Read

Synthetic genetic circuits to uncover and enforce the OCT4 trajectories of successful reprogramming of human fibroblastsSemantic proximity Read

Direct cell-fate conversion of somatic cells: Toward regenerative medicine and industriesSemantic proximity Read

The fate of cell reprogramming.Semantic proximity Read

Single cell expression analysis uncouples transdifferentiation and reprogrammingSemantic proximity Read

Modulating the epigenetic state promotes the reprogramming of transformed cells to pluripotency in a line-specific mannerSemantic proximity Read

A fast 2C-induction method reveals a barrier role of SP2 for totipotencySemantic proximity Read

scREMOTE: Using multimodal single cell data to predict regulatory gene relationships and to build a computational cell reprogramming modelSemantic proximity Read

Mechanisms for enhancing cellular reprogramming.Semantic proximity Read

Aligning single-cell developmental and reprogramming trajectories identifies molecular determinants of reprogramming outcomeSemantic proximity Read