Article

Branching and oscillations in the epigenetic landscape of cell-fate determination

2014-08-11

Abstract excerpt

The well-known Waddington’s epigenetic landscape of cell-fate determination is not static but varies because of the dynamic gene regulation during development. However, existing mathematical models with few state variables and fixed parameters are inadequate in characterizing the temporal transformation of the landscape. Here we simulate a decision-switch model of gene regulation with more than two state variables...

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Literature Corpus work: f4a839fa-7e10-576a-9270-bfa1a0f9cc96
DOI: 10.1101/007831

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