Article

Proliferation history and transcription factor levels drive direct conversion

2023-11-27

Abstract excerpt

The sparse and stochastic nature of reprogramming has obscured our understanding of how transcription factors drive cells to new identities. To overcome this limit, we developed a compact, portable reprogramming system that increases direct conversion of fibroblasts to motor neurons by two orders of magnitude. We show that subpopulations with different reprogramming potentials are distinguishable by proliferation...

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Identifiers and source

Literature Corpus work: 45334864-554c-588e-8044-81d6a9fbec15
DOI: 10.1101/2023.11.26.568736

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