Article

An enriched network motif family regulates multistep cell fate transitions with restricted reversibility

2018-10-25

Abstract excerpt

Multistep cell fate transitions with stepwise changes of transcriptional profiles are common to many developmental, regenerative and pathological processes. The multiple intermediate cell lineage states can serve as differentiation checkpoints or branching points for channeling cells to more than one lineages. However, mechanisms underlying these transitions remain elusive. Here, we explored gene regulatory circui...

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Literature Corpus work: 7c0f9fad-2497-5219-90ac-224ec57f4083
DOI: 10.1101/453522

Open publication

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