Article
Environment-Dependent Modes of Adaptive Evolution in Neuroblastoma: Plasticity as a Selectable Trait
2023-12-08
Abstract excerpt
Neuroblastoma, like many aggressive cancers, exhibits phenotypic heterogeneity, contributing to therapy resistance and disease progression. However, direct evidence of how phenotypic plasticity influences tumour evolution remains limited. Using a multi-resolution quantitative approach, we define the principles, types, and dynamics of plasticity in neuroblastoma at unprecedented resolution. We demonstrate that intr...
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Identifiers and source
- Literature Corpus work
- 081e96ad-709f-5224-a008-3c5d2e76f296
- DOI
- 10.1101/2023.12.07.570359