Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Apolipoprotein E: diversity of cellular origins, structural and biophysical properties, and effects in Alzheimer's disease.

Journal of molecular neuroscience : MN - 1 Jan 2004

Huang Yadong, Weisgraber Karl H, Mucke Lennart, Mahley Robert W

Abstract excerpt

Apolipoprotein E4 (apoE4) is a major risk factor for Alzheimer's disease (AD). Several hypotheses have been proposed to explain the association of the APOE epsilon4 allele with AD; however, the mechanisms underlying this association are largely unknown. Initially, apoE was thought to be synthesized primarily by astrocytes but not by neurons in the brain. However, subsequent studies have demonstrated that central...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Apolipoprotein E4

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Apolipoproteins E

Share to Astrocytes

Share to Models, Molecular

Share to Neurons

Share to Protein Conformation

Source

Identifiers

PMID: 15181247
DOI: 10.1385/JMN:23:3:189

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Apolipoprotein E: diversity of cellular origins, structural and biophysical properties, and effects in Alzheimer's disease.PMID 15181247Read ↗

Roles of apolipoprotein E4 (ApoE4) in the pathogenesis of Alzheimer's disease: lessons from ApoE mouse modelsSemantic proximity Read ↗

ApoE in Alzheimer's disease: pathophysiology and therapeutic strategies.Semantic proximity Read ↗

Unraveling APOE4's Role in Alzheimer's Disease: Pathologies and Therapeutic StrategiesSemantic proximity Read ↗

APOE4 is a Risk Factor and Potential Therapeutic Target for Alzheimer's DiseaseSemantic proximity Read ↗

APOE and Alzheimer’s Disease: From Lipid Transport to Physiopathology and TherapeuticsSemantic proximity Read ↗

Apolipoprotein E4 as a target for developing new therapeutics for Alzheimer's disease.Semantic proximity Read ↗

APOE and Alzheimer's Disease: Evidence Mounts that Targeting APOE4 may Combat Alzheimer's Pathogenesis.Semantic proximity Read ↗

The role of APOE4 in Alzheimer’s disease: strategies for future therapeutic interventionsSemantic proximity Read ↗

Alzheimer's disease phenotype based upon the carrier status of the apolipoprotein E ɛ4 allele.Semantic proximity Read ↗

Mechanisms linking apolipoprotein E isoforms with cardiovascular and neurological diseasesSemantic proximity Read ↗

Multi-functional role of apolipoprotein E in neurodegenerative diseasesSemantic proximity Read ↗

Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDSSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.