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Article

Alzheimer's disease phenotype based upon the carrier status of the apolipoprotein E ɛ4 allele.

Brain pathology (Zurich, Switzerland) - 1 Jan 2024

Ji Xiao-Yu, Peng Xin-Yuan, Tang Hai-Liang, Pan Hui, Wang Wei-Tang, Wu Jie, Chen Jian, Wei Nai-Li

Abstract excerpt

The apolipoprotein E ɛ4 allele (APOE4) is universally acknowledged as the most potent genetic risk factor for Alzheimer's disease (AD). APOE4 promotes the initiation and progression of AD. Although the underlying mechanisms are unclearly understood, differences in lipid-bound affinity among the three APOE isoforms may constitute the basis. The protein APOE4 isoform has a high affinity with triglycerides and...

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Identifiers

PMID: 37646624
DOI: 10.1111/bpa.13208
PMCID: PMC10711266

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