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Unraveling APOE4's Role in Alzheimer's Disease: Pathologies and Therapeutic Strategies

26 Dec 2024

Abstract excerpt

Alzheimer's disease (AD), the most common kind of dementia worldwide, is characterized by elevated levels of the amyloid-β (Aβ) peptide and hyperphosphorylated tau protein in the neurons. The complexity of AD makes the development of treatments infamously challenging. Apolipoprotein E (APOE) genes's ε4 allele is one of the main genetic risk factors for AD. While the APOE gene's ε4 allele considerably increases...

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PMID: 39722484
DOI: 10.2174/0113892037326839241014054430

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