Article
APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer's disease pathology and brain diseases.
Molecular neurodegeneration - 24 Sept 2022
Fernández-Calle Rosalía, Konings Sabine C, Frontiñán-Rubio Javier, García-Revilla Juan, Camprubí-Ferrer Lluís, Svensson Martina, Martinson Isak, Boza-Serrano Antonio, Venero José Luís, Nielsen Henrietta M, Gouras Gunnar K, Deierborg Tomas
Abstract excerpt
ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of the most influential risk factors for the development of late-onset Alzheimer's disease (AD). Neuroinflammation has become the third hallmark of AD, together with Amyloid-β plaques and neurofibrillary tangles of hyperphosphorylated aggregated...
Topics
- Humans
- Alzheimer Disease
- Amyloid beta-Peptides
- Apolipoprotein E2
- Apolipoprotein E3
- Apolipoprotein E4
- Apolipoproteins E
- Genotype
- Neurodegenerative Diseases
- Plaque, Amyloid
- tau Proteins