Article

Age-associated G-quadruplex accumulation and DDX5 loss shape chromatin landscapes in human astrocytes

2025-11-19

Abstract excerpt

<title>Abstract</title> <p> Aging disrupts genome organization and transcriptional fidelity, but the role of non-canonical DNA structures in the aging process remains unclear. G-quadruplexes (G4s), stable guanine-rich DNA and RNA structures are established regulators of gene expression and genome integrity, yet their contribution to physiological aging is unknown. Using fluorescent imaging with primary human ast...

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Literature Corpus work: c32c2fb0-381f-5f79-a948-3acc4bef36c9
DOI: 10.21203/rs.3.rs-7933297/v1

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