Article
Incorporation of a nucleoside analog maps genome repair sites in postmitotic human neurons.
Science (New York, N.Y.) - 2 Apr 2021
Reid Dylan A, Reed Patrick J, Schlachetzki Johannes C M, Nitulescu Ioana I, Chou Grace, Tsui Enoch C, Jones Jeffrey R, Chandran Sahaana, Lu Ake T, McClain Claire A, Ooi Jean H, Wang Tzu-Wen, Lana Addison J, Linker Sara B, Ricciardulli Anthony S, Lau Shong, Schafer Simon T, Horvath Steve, Dixon Jesse R, Hah Nasun, Glass Christopher K, Gage Fred H
Abstract excerpt
Neurons are the longest-lived cells in our bodies and lack DNA replication, which makes them reliant on a limited repertoire of DNA repair mechanisms to maintain genome fidelity. These repair mechanisms decline with age, but we have limited knowledge of how genome instability emerges and what strategies neurons and other long-lived cells may have evolved to protect their genomes over the human life span. A...
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