Article

Transcriptomic landscape and potential therapeutic targets for human testicular aging revealed by single-cell RNA sequencing

2022-12-14

Abstract excerpt

<h4>Background:</h4> Testicular aging is known to cause male age-related fertility decline and hypogonadism, but the underlying molecular mechanisms remain unclear. <h4>Methods:</h4> We survey the single-cell transcriptomic landscape of testes from young and old men and examine age-related changes in germline and somatic niche cells. <h4>Results:</h4> In-depth evaluation of the gene expression dynamics of germl...

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Literature Corpus work: 73a98685-d242-503c-8b52-d18cf5dc0b2f
DOI: 10.1101/2022.12.11.519976

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