Article

Identification of Novel Modulators of the ALT Pathway Through a Native FISH-Based Optical Screen

2024-11-15

Abstract excerpt

<h4>Summary</h4> A significant portion of human cancers utilize a recombination-based pathway, Alternative Lengthening of Telomeres (ALT), to extend telomeres. To gain further insights into this pathway, we developed a high-throughput imaging-based screen named TAILS (Telomeric ALT In situ Localization Screen), to identify genes that either promote or inhibit ALT activity. Screening over 1000 genes implicated in...

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Literature Corpus work: fd4ce981-166a-5e5b-857a-7a91e79185d7
DOI: 10.1101/2024.11.15.623791

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