Article

G-quadruplexes regulate chromatin accessibility and gene expression in Bloom Syndrome

2026-03-05

Abstract excerpt

Bloom Syndrome (BS) is a recessive genetic disorder characterized by hyper-recombination and genome instability. It is caused by mutations in BLM, which encodes a conserved RecQ helicase that unwinds various aberrant DNA structures. One such structure is DNA G-quadruplexes (G4s), which have versatile regulatory potential in chromatin organization and gene expression. However, whether G4 profiles are altered in BS...

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Literature Corpus work: ad6677c8-efcb-5944-9d64-b66617f81a86
DOI: 10.64898/2026.03.03.709275

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