Article

Enhanced chromatin compaction is associated with de novo expression of a nuclear microprotein, global loss of H3 acetylation and local transcriptional changes in retinal rod photoreceptors

2026-08-27

Abstract excerpt

<title>Abstract</title> We have limited understanding of how aging alters gene expression and remodels cellular architecture in post-mitotic neurons. The inverted nuclear organization of mouse rod photoreceptors provides a unique model to gain mechanistic insights into age-associated decline in neuronal function. We have generated and integrated multi-omic datasets including 3D-genome topology, histone modif...

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Literature Corpus work: 7d26a18e-7e8c-5ccc-827f-4b61e7addeb5
DOI: 10.21203/rs.3.rs-10017071/v1

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Enhanced chromatin compaction is associated with de novo expression of a nuclear microprotein, global loss of H3 acetylation and local transcriptional changes in retinal rod photoreceptorsDOI 10.21203/rs.3.rs-10017071/v1Read

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