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Article

Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritis

26 Jul 2019

Abstract excerpt

Abstract DiGeorge syndrome critical region 8 (DGCR8) is a critical component of the canonical microprocessor complex for microRNA biogenesis. However, the non-canonical functions of DGCR8 have not been studied. Here, we demonstrate that DGCR8 plays an important role in maintaining heterochromatin organization and attenuating aging. An N-terminal-truncated version of DGCR8 (DR8dex2) accelerated senescence in human...

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PMID: 31350386
DOI: 10.1038/s41467-019-10831-8

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