Article

BMI1-mediated heterochromatinization represses G-quadruplex DNA formation to maintain genomic stability during replication

2024-12-23

Abstract excerpt

<h4>Summary</h4> Single-stranded DNA secondary structures such as G-quadruplexes (G4s) can potentially disrupt transcription, replication, and repair. Using bio-informatic analysis, here we show that BMI1 is enriched at putative G4s flanked by heterochromatin domains, and that BMI1 knockdown in human dermal fibroblasts (HDFs) resulted in heterochromatin relaxation and G4 induction, followed by replication stress...

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Literature Corpus work: 72c07425-bf4d-5f44-b7f8-46ba7d4222b5
DOI: 10.1101/2024.12.23.630044

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