Article
Pan-cancer analysis of somatic copy-number alterations implicates IRS4 and IGF2 in enhancer hijacking.
Nature genetics - 1 Jan 2017
Weischenfeldt Joachim, Dubash Taronish, Drainas Alexandros P, Mardin Balca R, Chen Yuanyuan, Stütz Adrian M, Waszak Sebastian M, Bosco Graziella, Halvorsen Ann Rita, Raeder Benjamin, Efthymiopoulos Theocharis, Erkek Serap, Siegl Christine, Brenner Hermann, Brustugun Odd Terje, Dieter Sebastian M, Northcott Paul A, Petersen Iver, Pfister Stefan M, Schneider Martin, Solberg Steinar K, Thunissen Erik, Weichert Wilko, Zichner Thomas, Thomas Roman, Peifer Martin, Helland Aslaug, Ball Claudia R, Jechlinger Martin, Sotillo Rocio, Glimm Hanno, Korbel Jan O
Abstract excerpt
Extensive prior research focused on somatic copy-number alterations (SCNAs) affecting cancer genes, yet the extent to which recurrent SCNAs exert their influence through rearrangement of cis-regulatory elements (CREs) remains unclear. Here we present a framework for inferring cancer-related gene overexpression resulting from CRE reorganization (e.g., enhancer hijacking) by integrating SCNAs, gene expression data...
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