Article
A Compendium of Chromatin Contact Maps Reveals Spatially Active Regions in the Human Genome.
Cell reports - 15 Nov 2016
Schmitt Anthony D, Hu Ming, Jung Inkyung, Xu Zheng, Qiu Yunjiang, Tan Catherine L, Li Yun, Lin Shin, Lin Yiing, Barr Cathy L, Ren Bing
Abstract excerpt
The three-dimensional configuration of DNA is integral to all nuclear processes in eukaryotes, yet our knowledge of the chromosome architecture is still limited. Genome-wide chromosome conformation capture studies have uncovered features of chromatin organization in cultured cells, but genome architecture in human tissues has yet to be explored. Here, we report the most comprehensive survey to date of chromatin...
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