Article

Lessons from the analysis of TAD boundary deletions in normal population

2020-04-03

Abstract excerpt

Topologically Associating Domains (TAD)-boundaries induce spatial constraints, allowing interaction between regulatory elements and promoters only within their TAD. Their disruption could lead to disease, through gene-expression deregulation. This mechanism has been shown in only a relatively low number of diseases and a relatively low proportion of patients, raising the possibility of TAD boundary disruption with...

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Literature Corpus work: 07d5d419-1261-5bfd-b9ab-ea2938faee45
DOI: 10.1101/2020.04.01.021188

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