Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer

5 Feb 2020

Abstract excerpt

Chromatin is folded into successive layers to organize linear DNA. Genes within the same topologically associating domains (TADs) demonstrate similar expression and histone-modification profiles, and boundaries separating different domains have important roles in reinforcing the stability of these features. Indeed, domain disruptions in human cancers can lead to misregulation of gene expression. However, the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic factors in colorectal cancer
Share to Genomics and Chromatin Dynamics
Share to RNA Research and Splicing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32024999
DOI: 10.1038/s41588-019-0564-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Disruption of chromatin folding domains by somatic genomic rearrangements in human cancerPMID 32024999Read ↗

Spatial Genome Organization as a Framework for Somatic Alterations in Human CancerSemantic proximity Read ↗

Patterns of somatic structural variation in human cancer genomes.Semantic proximity Read ↗

Evolutionary stability of topologically associating domains is associated with conserved gene regulationSemantic proximity Read ↗

Somatic structural variation and cancer.Semantic proximity Read ↗

Selective and mechanistic sources of recurrent rearrangements across the cancer genomeSemantic proximity Read ↗

Diverse mechanisms of somatic structural variations in human cancer genomes.Semantic proximity Read ↗

Motif Disruption Domains Lead To Cancer Gene Expression RewiringSemantic proximity Read ↗

A comprehensive catalog of 3D genome organization in diverse human genomes facilitates understanding of the impact of structural variation on chromatin structureSemantic proximity Read ↗

Topologically associating domain (TAD) boundaries stable across diverse cell types are evolutionarily constrained and enriched for heritabilitySemantic proximity Read ↗

Pan-cancer analysis of somatic copy-number alterations implicates IRS4 and IGF2 in enhancer hijacking.Semantic proximity Read ↗

Dynamic interplay between structural variations and 3D chromosome organization in pancreatic cancerSemantic proximity Read ↗

When TADs go bad: chromatin structure and nuclear organisation in human diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.