Article

Chromatin features constrain structural variation across evolutionary timescales

2018-03-19

Abstract excerpt

The potential impact of structural variants includes not only the duplication or deletion of coding sequences, but also the perturbation of non-coding DNA regulatory elements and structural chromatin features, including topological domains (TADs). Structural variants disrupting TAD boundaries have been implicated both in cancer and developmental disease; this likely occurs via ‘enhancer hijacking’, whereby removal...

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Literature Corpus work: a2cd0f4f-88e8-5758-bf75-2f0376010989
DOI: 10.1101/285205

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