Article

Evolutionary stability of topologically associating domains is associated with conserved gene regulation

2017-12-09

Abstract excerpt

<h4>Background</h4> The human genome is highly organized in the three-dimensional nucleus. Chromosomes fold locally into topologically associating domains (TADs) defined by increased intra-domain chromatin contacts. TADs contribute to gene regulation by restricting chromatin interactions of regulatory sequences, such as enhancers, with their target genes. Disruption of TADs can result in altered gene expression a...

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Literature Corpus work: 080b0af6-cd8e-5102-b4a0-136aaafb4d35
DOI: 10.1101/231431

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