Article

Somatic structural variant formation is guided by and influences genome architecture

2021-05-18

Abstract excerpt

The occurrence and formation of genomic structural variants (SV) is known to be influenced by the 3D chromatin architecture, but the extent and magnitude has been challenging to study. Here, we apply Hi-C to study chromatin organization before and after induction of chromothripsis in human cells. We use Hi-C to manually assemble the derivative chromosomes following the massive complex rearrangements, which allowed...

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Literature Corpus work: 29853092-47f4-520d-a702-fcb6bb830105
DOI: 10.1101/2021.05.18.444682

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