Article
DASH/Dam1 complex mutants stabilize ploidy by weakening kinetochore-microtubule attachments
2022-09-28
Abstract excerpt
<h4>Summary</h4> Forcing budding yeast to chromatinize their DNA with human histones manifests an abrupt fitness cost. We previously proposed chromosomal aneuploidy and missense mutations as two potential modes of adaptation to histone humanization. Here we show that aneuploidy in histone-humanized yeasts is specific to a subset of chromosomes, defined by their centromeric evolutionary origins, however, they are...
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Identifiers and source
- Literature Corpus work
- c2f708ab-5e60-58cd-b1b7-736eea77021a
- DOI
- 10.1101/2022.09.28.509901