Article

Epigenetic regulation of genome integrity by a prion-based mechanism

2017-06-20

Abstract excerpt

<h4>ABSTRACT</h4> Epigenetic mechanisms mediate diverse gene expression programs in growth and development. Yet whether any can permanently alter the genome is unknown. Here we report a protein-based epigenetic element, a prion, formed by the conserved DNA helicase Mph1/FANCM. [ MPH1 + ] provides resistance to DNA damage, a gain-of-function trait that requires helicase activity and interactions with other DNA re...

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Literature Corpus work: eb1dee63-14ec-5392-9138-099c1337e374
DOI: 10.1101/152512

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