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Functional dissection of human mitotic genes using CRISPR-Cas9 tiling screens

2021-05-20

Abstract excerpt

<h4>SUMMARY</h4> Kinetochores are large protein complexes that assemble at the centromere and bind to mitotic spindle microtubules to ensure accurate chromosome segregation. Like most protein-coding genes, the full multifunctional nature of kinetochore factors remains uncharacterized due to the limited experimental tools for unbiased dissection of human protein sequences. We developed a method that leverages CRIS...

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Literature Corpus work
3424e216-7409-50cb-9f80-deba6e7546e9
DOI
10.1101/2021.05.20.445000
Open publication

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Functional dissection of human mitotic genes using CRISPR-Cas9 tiling screensDOI 10.1101/2021.05.20.445000
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