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Article

Fission yeast dam1-A8 mutant is resistant to and rescued by an anti-microtubule agent.

Biochemical and biophysical research communications - 11 Apr 2008

Griffiths Karen, Masuda Hirohisa, Dhut Susheela, Toda Takashi

Abstract excerpt

The Dam1/DASH outer kinetochore complex is required for high-fidelity chromosome segregation in budding and fission yeast. Unlike budding yeast, the fission yeast complex is non-essential, however it promotes bipolar microtubule attachment in conjunction with microtubule-depolymerising kinesin-8 Klp5 and Klp6. Here, we screened for dam1 temperature sensitive mutants in a klp5 null background and identified...

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Identifiers

PMID: 18262494
DOI: 10.1016/j.bbrc.2008.01.156

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Fission yeast dam1-A8 mutant is resistant to and rescued by an anti-microtubule agent.PMID 18262494Read ↗

The phosphorylation of a kinetochore protein Dam1 by Aurora B/Ipl1 kinase promotes chromosome bipolar attachment in yeast.Semantic proximity Read ↗

The fission yeast DASH complex is essential for satisfying the spindle assembly checkpoint induced by defects in the inner-kinetochore proteins.Semantic proximity Read ↗

CDC2 phosphorylation of the fission yeast dis1 ensures accurate chromosome segregation.Semantic proximity Read ↗

Mps1 phosphorylation of Dam1 couples kinetochores to microtubule plus ends at metaphase.Semantic proximity Read ↗

Two related kinesins, klp5+ and klp6+, foster microtubule disassembly and are required for meiosis in fission yeast.Semantic proximity Read ↗

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How Essential Kinesin-5 Becomes Non-Essential in Fission Yeast: Force Balance and Microtubule Dynamics Matter.Semantic proximity Read ↗

Fission yeast ch-TOG/XMAP215 homologue Alp14 connects mitotic spindles with the kinetochore and is a component of the Mad2-dependent spindle checkpoint.Semantic proximity Read ↗

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How Essential Kinesin-5 Becomes Non-Essential: Force Balance and Microtubule Dynamics MatterSemantic proximity Read ↗

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The Putative RNA-Binding Protein Dri1 Promotes the Loading of Kinesin-14/Klp2 to the Mitotic Spindle and Is Sequestered into Heat-Induced Protein Aggregates in Fission Yeast.Semantic proximity Read ↗

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