Article
Mitotic tethering enables <i>en masse</i> inheritance of a shattered micronuclear chromosome
2022-09-09
Abstract excerpt
<h4>Summary</h4> Chromothripsis, the shattering and imperfect reassembly of one (or a few) chromosome(s) 1 , is an ubiquitous 2 mutational process generating localized complex chromosomal rearrangements that drive genome evolution in cancer. Chromothripsis can be initiated by missegregation errors in mitosis 3,4 or DNA metabolism 5-7 that lead to entrapment of chromosomes within micronuclei and their subseque...
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Identifiers and source
- Literature Corpus work
- 60371c39-ad67-5720-9cf0-23558f401f8f
- DOI
- 10.1101/2022.09.08.507171