Article
Mechanisms Generating Cancer Genome Complexity From A Single Cell Division Error
2019-11-07
Abstract excerpt
<h4>ABSTRACT</h4> The chromosome breakage-fusion-bridge (BFB) cycle is a mutational process that produces gene amplification and genome instability. Signatures of BFB cycles can be observed in cancer genomes with chromothripsis, another catastrophic mutational process. Here, we explain this association by identifying a mutational cascade downstream of chromosome bridge formation that generates increasing amounts...
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Identifiers and source
- Literature Corpus work
- 782ac193-a7d7-56a4-9428-fd358395a5d0
- DOI
- 10.1101/835058