Article
Resetting the Yeast Epigenome with Human Nucleosomes.
Cell - 14 Dec 2017
Truong David M, Boeke Jef D
Abstract excerpt
Humans and yeast are separated by a billion years of evolution, yet their conserved histones retain central roles in gene regulation. Here, we "reset" yeast to use core human nucleosomes in lieu of their own (a rare event taking 20 days), which initially only worked with variant H3.1. The cells adapt by acquiring suppressor mutations in cell-division genes or by acquiring certain aneuploid states. Converting five...
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