Article

Human macroH2A1 drives nucleosome dephasing and genome instability in histone-humanized yeast

2023-05-06

Abstract excerpt

<h4>Summary</h4> In addition to replicative histones, eukaryotic genomes encode a repertoire of non-replicative variant histones providing additional layers of structural and epigenetic regulation. Here, we systematically replaced individual replicative human histones with non-replicative human variant histones using a histone replacement system in yeast. Variants H2A.J, TsH2B, and H3.5 complemented for their res...

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Literature Corpus work: e9c95273-f47a-5300-9678-b02dfd483f10
DOI: 10.1101/2023.05.06.538725

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