Article
Resetting the yeast epigenome with human nucleosomes
2017-06-07
Abstract excerpt
<h4>Summary</h4> Humans and yeast are separated by a billion years of evolution, yet their conserved core histones retain central roles in gene regulation. Here, we “reset” yeast to use core human nucleosomes in lieu of their own, an exceedingly rare event which initially took twenty days. The cells adapt, however, by acquiring suppressor mutations in cell-division genes, or by acquiring certain aneuploidy states...
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Identifiers and source
- Literature Corpus work
- 98451066-1840-55c2-b9ab-ed14a8d1ebe3
- DOI
- 10.1101/147264