Article

R1398 is the GTP-𝛾-phosphate sensor that drives the ROC G-domain switching mechanism unique to Parkinson's disease-associated LRRK2

2026-07-01

Abstract excerpt

<title>Abstract</title> <p>Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson’s disease (PD). Strategies that directly inhibit the LRRK2 kinase active site have not demonstrated disease-modifying efficacy in recent clinical testing. A naturally occurring protective variant, R1398H, provides an alternative route for understanding how reduced disease risk may be achieve...

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Literature Corpus work: 65e75c03-549c-5f4c-956f-10daf265ad53
DOI: 10.21203/rs.3.rs-10121216/v1

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