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Structural biology of Parkinson’s disease-associated leucine-rich repeat kinase 2 (LRRK2)

14 Jun 2025

Abstract excerpt

Leucine-rich repeat kinase 2 (LRRK2) has gone, in a little over 2 decades, from a novel gene linked to cases of Parkinson's disease (PD) in one family to being the main actionable target for PD therapeutics, with several clinical trials targeting it currently underway. While much remains to be understood about LRRK2-including, chiefly, why its increased activity is linked to PD-much has also been learned. One of...

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PMID: 40523620
DOI: 10.1016/j.jbc.2025.110376

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