Article
Contribution of GTPase activity to LRRK2-associated Parkinson disease.
Small GTPases - 1 Jan 2000
Tsika Elpida, Moore Darren J
Abstract excerpt
Mutations in the leucine-rich repeat kinase 2 (LRRK2, PARK8, OMIM 607060) gene represent the most common known cause of hereditary Parkinson's disease (PD) with late-onset and dominant inheritance. LRRK2 protein is composed of multiple domains including two distinct enzymatic domains, a kinase an...
Topics
- GTP Phosphohydrolases
- Humans
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Parkinson Disease
- Polymorphism, Single Nucleotide
- Protein Serine-Threonine Kinases
- Protein Structure, Tertiary