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Article

LRRK2: Molecular Mechanisms in Parkinson's Disease.

International journal of molecular sciences - 25 Aug 2026

Arias-Carrión Oscar, Guerra-Crespo Magdalena, Ortuño-Sahagún Daniel, Ortega-Robles Emmanuel

Abstract excerpt

Leucine-rich repeat kinase 2 (LRRK2) has emerged as a central molecular node linking genetic risk, membrane trafficking, lysosomal homeostasis, and immune signalling in Parkinson's disease (PD). Rather than functioning as a conventional protein kinase, LRRK2 operates as a conformationally regulated, Rab-directed signalling machine whose activity is governed by long-range interdomain communication, membrane...

Read the complete abstract on PubMed

Topics

Humans
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
Parkinson Disease
Animals
rab GTP-Binding Proteins
Signal Transduction

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mutation

Phosphorylation

Lysosomes

Source

Open in PubMed Open full text

Identifiers

PMID: 42737506
DOI: 10.3390/ijms27177606
PMCID: PMC13565929

Genes

PPM1H

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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LRRK2: Molecular Mechanisms in Parkinson's Disease.PMID 42737506Read ↗

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LRRK2 Biology from structure to dysfunction: research progresses, but the themes remain the same.Semantic proximity Read ↗

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LRRK2: from kinase to GTPase to microtubules and back.Semantic proximity Read ↗

Conformation and dynamics of the kinase domain drive subcellular location and activation of LRRK2Semantic proximity Read ↗

Rab12 is a regulator of LRRK2 and its activation by damaged lysosomes.Semantic proximity Read ↗

LRRK2 kinase dependent and independent function on endolysosomal repair promotes macrophage cell deathSemantic proximity Read ↗

Leucine-rich repeat kinase 2 (LRRK2): balancing cellular homeostasis and Parkinson's disease (PD) pathogenesis.Semantic proximity Read ↗

The Role of LRRK2 in Intracellular Organelle Dynamics.Semantic proximity Read ↗

The structural basis for LRRK2’s activation and autoinhibitionSemantic proximity Read ↗

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