Article
Understanding the GTPase Activity of LRRK2: Regulation, Function, and Neurotoxicity.
Advances in neurobiology - 1 Jan 2017
Nguyen An Phu Tran, Moore Darren J
Abstract excerpt
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most frequent cause of Parkinson's disease (PD) with late-onset and autosomal-dominant inheritance. LRRK2 belongs to the ROCO superfamily of proteins, characterized by a Ras-of-complex (Roc) GTPase domain in tandem with a C-terminal-of-Roc (COR) domain. LRRK2 also contains a protein kinase domain adjacent to the Roc-COR tandem domain in addition...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.