Article

Adaptive Suppression of MAPT Transcription Maintains Tau Proteostasis in Developing Human Neurons

2025-10-03

Abstract excerpt

<title>Abstract</title> <p>Developing human neurons express abundant tau yet show little toxicity, suggesting built-in mechanisms that restrain tau when protein clearance falters. We combined human tissue analyses with cell-based perturbation assays to define this response. In iPSC-derived forebrain neurons, brief proteasome blockade with epoxomicin (0.25 µM, 24 h; n=3/condition) triggered a coordinated transcrip...

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Literature Corpus work: c2bbae20-bb5d-58cd-b8e5-c2de63c162e5
DOI: 10.21203/rs.3.rs-7585327/v1

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