Article

Tau Ablation Rewires Brain Cell Programs in Health and Restores Function in Disease

2026-05-17

Abstract excerpt

<h4>ABSTRACT</h4> Tau is a microtubule-associated protein with diverse roles in the healthy brain but contributes to neurodegenerative disorders when dysregulated. Although tau ablation has shown protective effects in several disease models, how its absence confers this protection remain unclear. Here, we performed and analyzed single-nucleus RNA sequencing on cortices of aged tau knockout ( Mapt ⁻/⁻ ) mice in...

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Literature Corpus work: ce53aba5-9c53-549f-a470-e397d34aadf4
DOI: 10.64898/2026.05.12.724684

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