Article

Multi-omic phenotyping of <i>MAPT</i> V337M neurons reveals early changes in axonogenesis and tau phosphorylation

2024-06-06

Abstract excerpt

Tau aggregation is a hallmark of several neurodegenerative diseases, including Alzheimer’s disease and frontotemporal dementia. There are disease-causing variants of the tau-encoding gene, MAPT , and the presence of tau aggregates is highly correlated with disease progression. However, the molecular mechanisms linking pathological tau to neuronal dysfunction are not well understood. This is in part due to an inco...

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Literature Corpus work: b969e519-bcb8-5741-906d-1fe135b86d6a
DOI: 10.1101/2024.06.04.597496

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Multi-omic phenotyping of <i>MAPT</i> V337M neurons reveals early changes in axonogenesis and tau phosphorylationDOI 10.1101/2024.06.04.597496Read

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