Article

Integrated Manufacturing Platform for Cortical Organoids Reveals Early Phosphatase and Prefoldin Dysregulation in <i>MAPT</i> V337M Neurons

2023-07-11

Abstract excerpt

<h4>Summary</h4> Human pluripotent stem cell (hPSC)-derived cortical organoids are powerful models but are often limited by low efficiency, variability, and stress-related artifacts. To address these challenges, we developed a scalable organoid platform with end-to-end quality control (QC) metrics spanning manufacturing and single-cell RNA-sequencing (scRNA-seq), developed using eight MAPT mutation isogenic line...

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Literature Corpus work: d6d3eeee-b296-52eb-aeef-f546b66e46bc
DOI: 10.1101/2023.07.11.548571

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