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Genome-wide CRISPR screen identifies protein pathways modulating tau protein levels in neurons

14 Jun 2021

Abstract excerpt

Aggregates of hyperphosphorylated tau protein are a pathological hallmark of more than 20 distinct neurodegenerative diseases, including Alzheimer's disease, progressive supranuclear palsy, and frontotemporal dementia. While the exact mechanism of tau aggregation is unknown, the accumulation of aggregates correlates with disease progression. Here we report a genome-wide CRISPR screen to identify modulators of...

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PMID: 34127790
DOI: 10.1038/s42003-021-02272-1

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