Article

Pluripotent stem cell derived models of neurological diseases reveal early transcriptional heterogeneity

2020-12-02

Abstract excerpt

<h4>Background</h4> Many neurodegenerative diseases (NDs) develop only later in life, when cells in the nervous system lose their structure or function. In genetic forms of NDs, this late onset phenomenon remains largely unexplained. <h4>Results</h4> Analyzing single cell RNA sequencing (scRNA-seq) from Alzheimer’s disease (AD) patients, we find increased transcriptional heterogeneity in AD excitatory neurons. W...

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Literature Corpus work: 7355773a-a873-59dc-bb8c-6c6fc28f7789
DOI: 10.1101/2020.12.02.398263

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