Article

Integrative multiomics reveals common endotypes across PSEN1, PSEN2, and APP mutations in familial Alzheimer’s disease

2022-12-09

Abstract excerpt

<title>Abstract</title> <p>Background Mutations in PSEN1, PSEN2, and APP can lead to Alzheimer’s disease (AD) with an early age at onset (AAO) and hallmark progressive cognitive decline. These mutations are highly penetrant. Although mutations in PSEN1 are more common and usually have an earlier AAO, certain mutations in PSEN1 cause a later AAO, similar to PSEN2 and APP mutations. We sought to determine whether c...

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Literature Corpus work: e79f4db2-6771-5899-b913-f12abc3f6db3
DOI: 10.21203/rs.3.rs-2356131/v1

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